Frequency of C3435T polymorphism of MDR1 gene in African people.
Identifieur interne : 001075 ( Main/Exploration ); précédent : 001074; suivant : 001076Frequency of C3435T polymorphism of MDR1 gene in African people.
Auteurs : E. Schaeffeler ; M. Eichelbaum ; U. Brinkmann ; A. Penger ; S. Asante-Poku ; U M Zanger ; M. SchwabSource :
- Lancet (London, England) [ 0140-6736 ] ; 2001.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : P-Glycoprotein.
- geographic : Ghana.
- genetics : Genes, MDR.
- African Continental Ancestry Group, Asian Continental Ancestry Group, European Continental Ancestry Group, Gene Frequency, Genotype, Humans, Polymorphism, Genetic, Random Allocation.
Abstract
The variability of P-glycoprotein expression between individuals is linked to a C3435T polymorphism of the human MDR1 gene. Concentration of P-glycoprotein in intestinal epithelial cells and in a subset of lymphoid cells is substantially lower in people with the T/T genotype than those with the C/C genotype. We compared allele frequencies of the C3435T polymorphism in random samples of west African, African American, white, and Japanese people. We recorded a significantly higher frequency of the C/C genotype in West Africans and African Americans (142 of 172 [83%] and 25 of 41 [61%], respectively), than in white people (139 of 537 [26%]) (p<0.0001). These findings could affect use of drugs that are P-glycoprotein substrates (such as HIV-1 protease inhibitors and ciclosporin) in African populations.
DOI: 10.1016/S0140-6736(01)05579-9
PubMed: 11502320
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000786
- to stream PubMed, to step Curation: 000786
- to stream PubMed, to step Checkpoint: 000786
- to stream Ncbi, to step Merge: 000043
- to stream Ncbi, to step Curation: 000043
- to stream Ncbi, to step Checkpoint: 000043
- to stream Main, to step Merge: 001145
- to stream Main, to step Curation: 001075
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Frequency of C3435T polymorphism of MDR1 gene in African people.</title><author><name sortKey="Schaeffeler, E" sort="Schaeffeler, E" uniqKey="Schaeffeler E" first="E" last="Schaeffeler">E. Schaeffeler</name></author><author><name sortKey="Eichelbaum, M" sort="Eichelbaum, M" uniqKey="Eichelbaum M" first="M" last="Eichelbaum">M. Eichelbaum</name></author><author><name sortKey="Brinkmann, U" sort="Brinkmann, U" uniqKey="Brinkmann U" first="U" last="Brinkmann">U. Brinkmann</name></author><author><name sortKey="Penger, A" sort="Penger, A" uniqKey="Penger A" first="A" last="Penger">A. Penger</name></author><author><name sortKey="Asante Poku, S" sort="Asante Poku, S" uniqKey="Asante Poku S" first="S" last="Asante-Poku">S. Asante-Poku</name></author><author><name sortKey="Zanger, U M" sort="Zanger, U M" uniqKey="Zanger U" first="U M" last="Zanger">U M Zanger</name></author><author><name sortKey="Schwab, M" sort="Schwab, M" uniqKey="Schwab M" first="M" last="Schwab">M. Schwab</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11502320</idno><idno type="pmid">11502320</idno><idno type="doi">10.1016/S0140-6736(01)05579-9</idno><idno type="wicri:Area/PubMed/Corpus">000786</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000786</idno><idno type="wicri:Area/PubMed/Curation">000786</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000786</idno><idno type="wicri:Area/PubMed/Checkpoint">000786</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000786</idno><idno type="wicri:Area/Ncbi/Merge">000043</idno><idno type="wicri:Area/Ncbi/Curation">000043</idno><idno type="wicri:Area/Ncbi/Checkpoint">000043</idno><idno type="wicri:doubleKey">0140-6736:2001:Schaeffeler E:frequency:of:c</idno><idno type="wicri:Area/Main/Merge">001145</idno><idno type="wicri:Area/Main/Curation">001075</idno><idno type="wicri:Area/Main/Exploration">001075</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Frequency of C3435T polymorphism of MDR1 gene in African people.</title><author><name sortKey="Schaeffeler, E" sort="Schaeffeler, E" uniqKey="Schaeffeler E" first="E" last="Schaeffeler">E. Schaeffeler</name></author><author><name sortKey="Eichelbaum, M" sort="Eichelbaum, M" uniqKey="Eichelbaum M" first="M" last="Eichelbaum">M. Eichelbaum</name></author><author><name sortKey="Brinkmann, U" sort="Brinkmann, U" uniqKey="Brinkmann U" first="U" last="Brinkmann">U. Brinkmann</name></author><author><name sortKey="Penger, A" sort="Penger, A" uniqKey="Penger A" first="A" last="Penger">A. Penger</name></author><author><name sortKey="Asante Poku, S" sort="Asante Poku, S" uniqKey="Asante Poku S" first="S" last="Asante-Poku">S. Asante-Poku</name></author><author><name sortKey="Zanger, U M" sort="Zanger, U M" uniqKey="Zanger U" first="U M" last="Zanger">U M Zanger</name></author><author><name sortKey="Schwab, M" sort="Schwab, M" uniqKey="Schwab M" first="M" last="Schwab">M. Schwab</name></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="ISSN">0140-6736</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>African Continental Ancestry Group</term><term>Asian Continental Ancestry Group</term><term>European Continental Ancestry Group</term><term>Gene Frequency</term><term>Genes, MDR (genetics)</term><term>Genotype</term><term>Ghana</term><term>Humans</term><term>P-Glycoprotein (genetics)</term><term>Polymorphism, Genetic</term><term>Random Allocation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Attribution aléatoire</term><term>Fréquence d'allèle</term><term>Ghana</term><term>Glycoprotéine P (génétique)</term><term>Gènes MDR (génétique)</term><term>Génotype</term><term>Humains</term><term>Polymorphisme génétique</term><term>Population d'origine africaine</term><term>Population d'origine asiatique</term><term>Population d'origine européenne</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>P-Glycoprotein</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genes, MDR</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine P</term><term>Gènes MDR</term></keywords><keywords scheme="MESH" xml:lang="en"><term>African Continental Ancestry Group</term><term>Asian Continental Ancestry Group</term><term>European Continental Ancestry Group</term><term>Gene Frequency</term><term>Genotype</term><term>Humans</term><term>Polymorphism, Genetic</term><term>Random Allocation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Attribution aléatoire</term><term>Fréquence d'allèle</term><term>Ghana</term><term>Génotype</term><term>Humains</term><term>Polymorphisme génétique</term><term>Population d'origine africaine</term><term>Population d'origine asiatique</term><term>Population d'origine européenne</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The variability of P-glycoprotein expression between individuals is linked to a C3435T polymorphism of the human MDR1 gene. Concentration of P-glycoprotein in intestinal epithelial cells and in a subset of lymphoid cells is substantially lower in people with the T/T genotype than those with the C/C genotype. We compared allele frequencies of the C3435T polymorphism in random samples of west African, African American, white, and Japanese people. We recorded a significantly higher frequency of the C/C genotype in West Africans and African Americans (142 of 172 [83%] and 25 of 41 [61%], respectively), than in white people (139 of 537 [26%]) (p<0.0001). These findings could affect use of drugs that are P-glycoprotein substrates (such as HIV-1 protease inhibitors and ciclosporin) in African populations.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Asante Poku, S" sort="Asante Poku, S" uniqKey="Asante Poku S" first="S" last="Asante-Poku">S. Asante-Poku</name><name sortKey="Brinkmann, U" sort="Brinkmann, U" uniqKey="Brinkmann U" first="U" last="Brinkmann">U. Brinkmann</name><name sortKey="Eichelbaum, M" sort="Eichelbaum, M" uniqKey="Eichelbaum M" first="M" last="Eichelbaum">M. Eichelbaum</name><name sortKey="Penger, A" sort="Penger, A" uniqKey="Penger A" first="A" last="Penger">A. Penger</name><name sortKey="Schaeffeler, E" sort="Schaeffeler, E" uniqKey="Schaeffeler E" first="E" last="Schaeffeler">E. Schaeffeler</name><name sortKey="Schwab, M" sort="Schwab, M" uniqKey="Schwab M" first="M" last="Schwab">M. Schwab</name><name sortKey="Zanger, U M" sort="Zanger, U M" uniqKey="Zanger U" first="U M" last="Zanger">U M Zanger</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaGhanaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001075 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001075 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= SidaGhanaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:11502320
|texte= Frequency of C3435T polymorphism of MDR1 gene in African people.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:11502320" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SidaGhanaV1
| This area was generated with Dilib version V0.6.31. |  |